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Red Wine Makes You Thin!??
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Wine Health with Bex Bishop, Winemaker at BX of Napa

sirtuin

Red Wine Compound Activates Gene Needed for Healthy Cells

More on the debate on the effectiveness and amount of resveratrol in humans...
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Harvard scientists said they have settled a debate over whether a compound found in red wine activates a gene that keeps cells healthy.

Researchers repeated a 10-year old study using a new method to validate earlier findings that resveratrol turns on a gene that recharges mitochondria, tiny structures that produce fuel for cells. By revving up mitochondria, the agent may protect against aging-related diseases, said David Sinclair, a Harvard Medical School genetics professor and the study’s senior author.

Sinclair’s earlier research was disputed in studies in 2009 and 2010 saying that resveratrol only activated the gene, a sirtuin called SIRT1, in experiments that used a synthetic fluorescent chemical to track activity. Since these chemicals aren’t found in cells or nature, other studies said the effect would only work in lab tests and not in humans. The new study, published today in the journal Science, got rid of the chemical.

“Controversy is a difficult thing to deal with, and I hope this paper gives some clarity to the field,” Sinclair said in a telephone interview.

The Harvard group set out to see if the effect was an artifact of the synthetic chemicals or was something that occurred naturally as well. They swapped out the fluorescent chemicals for a group of naturally occurring amino acids, including tryptophan, and found resveratrol did activate SIRT1.

Resveratrol Drugs
Sinclair’s earlier work led to the formation of Sirtris Pharmaceuticals which focuses on developing drugs from resveratrol. GlaxoSmithKline Plc (GSK) acquired the company in 2008 for $720 million. A little more than two years later, Glaxo shelved development of the lead compound from that acquisition, SRT501, when the medicine didn’t appear to work well enough in cancer patients and worsened kidney damage.

Resveratrol is currently being tested in at least two dozen clinical trials to gauge its effects on human health. It’s also packaged as a natural supplement, with $34 million in U.S. sales last year, according to the Nutrition Business Journal.

Further doubt was cast on resveratrol’s abilities after a prominent researcher and promoter of the compound, Dipak Das, who was the director of the University of Connecticut Health Center’s cardiovascular research center, was found to have fabricated and falsified data in numerous studies...

To contact the reporter on this story: Ryan Flinn in San Francisco at rflinn@bloomberg.net



Resveratrol is back on again - saving you from aging! Well, almost...

Resveratrol certainly is good for you. But how good, how much is needed, and under what circumstances seems be the big question. Well, hallelujah, a new research says... well, in short, go ahead and feel good about drinking your glass of red wine again.
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Red wine molecule could be healthy
Grab a glass of red - it seems to be a rejuvenating drink again. Red wine goes in and out of health fashion. But now it's back as a possible preventer or fighter of aging diseases. 

That good news for wine lovers comes thanks to the efforts of 30 researchers from around the globe. They've produced a paper saying that under certain conditions SIRT1, the human sirtuin protein known to combat many age-related diseases, can be activated by resveratrol and other sirtuin-activating compounds (STACs)...