BX of Napa Wines - In progress: please sit back & have wine w/me while I work...
RSS Follow Become a Fan

Delivered by FeedBurner

Recent Posts

Drinking Wine is Better Than Going to the Gym, According to Scientists
Red Wine Makes You Thin!??
Cheers to our HEALTH! Really. "Champagne" [sparkling wines] are good for you
Bex, BX Bubbles, Champagne, Prosseco ... and the town of Prošek
Low-Cal Cocktails (Even Tho Wine is Healthiest)


food pairing
French Paradox
Low alcohol
Pinot Grigio
social media
Vinho Verde
Wine Genome Project
powered by

Wine Health with Bex Bishop, Winemaker at BX of Napa

“Conclusive Evidence” for Red Wine's Health and Longevity Benefits

Researchers have demonstrated what they consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models. Furthermore, the Harvard Medical School team uncovered the molecular mechanism for this interaction, and they show that a class of more potent drugs currently in clinical trials acts in a similar fashion. 

Pharmaceutical compounds similar to resveratrol may potentially treat and prevent diseases related to aging in people, the researchers contend. Studies over the last decade have demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries, increases the activity of a specific sirtuin, SIRT1, that protects the body from diseases by revving up the mitochondria. Mice on resveratrol have twice the endurance and are relatively immune from effects of obesity and aging. In experiments with yeast, nematodes, bees, flies, and mice, lifespan has been extended.

"In the history of pharmaceuticals, there has never been a drug that binds to a protein to make it run faster in the way that resveratrol activates SIRT1," says David Sinclair, Harvard Medical School professor of genetics and senior author on the paper. "Almost all drugs either slow or block them."
The authors thus propose a model for how resveratrol works: When the molecule binds, a hinge flips, and SIRT1 becomes hyperactive. Although these experiments occurred in a test tube, once the researchers identified the precise location of the accelerator pedal on SIRT1—and how to break it—they could test their ideas in a cell. They replaced the normal SIRT1 gene in muscle and skin cells with the accelerator-dead mutant. Now they could test precisely whether resveratrol and the drugs in development work by tweaking SIRT1 (in which case they would not work) or one of the thousands of other proteins in a cell (in which they would work). While resveratrol and the drugs tested revved up mitochondria in normal cells (an effect caused activating by SIRT1), the mutant cells were completely immune.

"There is no rational alternative explanation other than resveratrol directly activates SIRT1 in cells,” says Sinclair. “Now that we know the exact location on SIRT1 where and how resveratrol works, we can engineer even better molecules that more precisely and effectively trigger the effects of resveratrol."

34 Comments to “Conclusive Evidence” for Red Wine's Health and Longevity Benefits:

Comments RSS
online rsa qld on Thursday, March 21, 2013 1:21 AM
This was important information regarding health benefits of red wine. I am glad to come across this blog!
Reply to comment
laser hair removal melbourne on Monday, May 06, 2013 1:47 AM
Thanks for this information about the red wine in about the ingredient of wine this is very important information for me. Thanks..

cataract on Thursday, June 13, 2013 4:14 AM
I have no idea about that red wine has helps to prevent aging. That was a good topic shared by you.

Remedial Massage Course Brisbane on Wednesday, June 26, 2013 1:08 AM
Is wine healthy? In moderation and as part of an overall healthy diet, the short answer is yes!Keep up the great work! You already know, many persons are searching round for this info, you could aid them greatly.!!

Dentist in Rockville on Monday, March 25, 2013 2:43 AM
A precious useful evidence for health which affects due to Red Wine's impressed me and over exceeded my expectation to know about it. Such a nice and informative blog about health issues you have given to us. Keep sharing.
Reply to comment
Buy Trimthin SR on Tuesday, June 11, 2013 10:45 PM
Oh! my God are you serious, i mean i just can not believe that wine can be beneficial for health. It is something which always been an controversial thing which our parents and elder restrict us to drink. But i heartily thank you for clearing this myth.

Clear braces NYC on Tuesday, April 02, 2013 8:50 PM
I agree with your Conclusive Evidence suitable for Red Wine's Health and Longevity Benefits which is really very interesting. All the information given about it in this blog is too much useful for people. Thanks for sharing.
Reply to comment

laser eye surgery on Thursday, April 11, 2013 4:57 AM
I liked the way you put together everything, there is certainly no need to go any further to look for any additional information.like your blog thanks for sharing...
Reply to comment

responsible service of alcohol on Thursday, April 18, 2013 9:57 PM
Thanks for choosing this topic to write on Wine Health with Bex Bishop, Winemaker at BX of Napa. This post is of considerable use for me and my friends. Great experience has been shared with us. Thanks for this post.
Reply to comment

Laviera Steve on Wednesday, April 24, 2013 6:07 AM
You made my day! I am very happy and relaxed too that I find this blog. I was looking for the matter discussed in blog post. If you have some more blogs on the material please share those as well. Thanks a lot and keep sharing such useful information. Enormous information in one blog post, I just love it. I must appreciate and mention that you completely know how to keep connected reader to blog post even if it is little long. Very good job.
Reply to comment

Benzocaine Powder on Thursday, April 25, 2013 11:35 PM
This information about red wine that is its compound resveratrol directly activates a protein that is promote our health, is very useful and knowledgeable for me.
Reply to comment

http://www.slotmachine-gratis.it on Saturday, May 11, 2013 4:08 AM
Now that we know the exact location on SIRT1 where and how resveratrol works, we can engineer even better molecules that more precisely and effectively trigger the effects of resveratrol."
Reply to comment

Body Contouring Sydney on Friday, May 17, 2013 1:54 AM
That is so informative that red-wine compound directly activates a protein that promotes health and longevity in animal models.Researchers did the very nice job.
Reply to comment

glass clamp on Friday, May 17, 2013 11:49 PM
if you add google sever to your domain name serve, your website will point to a google site... i made that mistake
Reply to comment

tibet tourism on Sunday, May 19, 2013 2:31 AM
obviously like your web-site however you need to test the spelling on several of your posts. Many of them are rife with spelling problems and I find it very bothersome to inform the reality nevertheless I will definitely come back again.
Reply to comment

http://www.cavallimania.it on Monday, May 20, 2013 5:21 AM
Medical School team uncovered the molecular mechanism for this interaction, and they show that a class of more potent drugs currently in clinical trials acts in a similar fashion.
Reply to comment

dentist surrey on Monday, May 20, 2013 6:26 AM
There are a lot of benefits of red wine in health.It improves our health in a lot of ways.
Reply to comment

Burnaby dental on Monday, May 20, 2013 6:29 AM
Thanks for sharing this research about the red wine.Thanks and keep blogging.
Reply to comment

Dentist Langley on Monday, May 20, 2013 6:44 AM
Red wine contains the proteins that will make our health good and add a lot of advantages in our health.
Reply to comment

writing service on Saturday, June 15, 2013 2:30 AM
This mail was very well in writing, and it furthermore comprises a lot of helpful facts. I relished your differentiated way of writing the mail.
Reply to comment

My site on Monday, July 01, 2013 8:28 AM
will come back again for check more
Reply to comment

car accident lawyer in sydeny for compansation on Thursday, July 04, 2013 5:55 AM
" Well, the article is actually the sweetest topic on this related issue. I fit in with your conclusions and will thirstily look forward to your forthcoming updates. "
Reply to comment

Drug testing for marijuana on Monday, July 08, 2013 6:41 AM
It is very interesting that red-wine compound resveratrol directly activates a protein that promotes health.Thank you so much for sharing such a delightful content.
Reply to comment

slot machine on Friday, July 19, 2013 3:28 AM
The authors thus propose a model for how resveratrol works: When the molecule binds, a hinge flips, and SIRT1 becomes hyperactive.
Reply to comment

click here to know on Thursday, August 01, 2013 3:00 AM
Excellent post. Keep writing such kind of info on your page. Im really impressed by your site. Thanks for sharing your thoughts about disorders..Thanks!!
Reply to comment

Buy Cancer Drugs on Friday, August 09, 2013 4:35 AM
It's really nice information provided by you. Nice topics and nice information. Thanks for sharing this with us.
Reply to comment

does the flex belt work on Wednesday, August 28, 2013 5:17 AM
I believe that is one of the so much significant info for me. And i'm satisfied studying your article. But wanna remark on some common issues, The web site taste is perfect, the articles is really nice : D. Just right activity, cheers..!!
Reply to comment

pure-powder on Wednesday, September 04, 2013 5:19 AM
Pharmaceutical companies are manufacturing many drugs which helps to keep healthy and younger and also fair.
Reply to comment

buy cheap essay on Thursday, November 07, 2013 5:18 AM
A Home Inspector can advise you on estimated costs to repair any problems as well as offer advice of the life expectancy of the various aspects of the house.
Reply to comment

replique de montre on Monday, December 16, 2013 6:56 PM
Always are good posts and topics please keep it up!I will track your article all the time .Thanks for your hard work
Reply to comment

food allergy testing on Friday, June 06, 2014 10:37 PM
The first time I came here, less than 10 seconds the display is perfectly open, and the loading is completed less than 20 seconds and to open the article only took about 7 seconds. So I think this is very fast! Incredible! Trying to maintain!!!!
Reply to comment

mechanical watches on Wednesday, January 07, 2015 6:15 PM
An interesting dialogue is price comment. I feel that you should write extra on this matter, it may not be a taboo topic but usually individuals are not enough to talk on such topics. To the next. Cheers
Reply to comment

Buy Sanitary Pads on Wednesday, April 06, 2016 1:36 AM
Thanks for sharing the post. It was really helpful.
Reply to comment

Vicky Taylor on Wednesday, May 18, 2016 4:23 AM
Interessante. In effetti sono tanti. Sarebbe bello capire se esiste esistono case study reali di applicazioni sviluppate con questi NoSql DB e un confronto tra i vari prodotti in circolazione. Esempio sviluppando in .net (c#, linq, silver) e dovendo gestire milioni di file, quale scegliere?
Reply to comment

Add a Comment

Your Name:
Email Address: (Required)
Make your text bigger, bold, italic and more with HTML tags. We'll show you how.
Post Comment