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Wine Health with Bex Bishop, Winemaker at BX of Napa

Red Wine Compound Activates Gene Needed for Healthy Cells

More on the debate on the effectiveness and amount of resveratrol in humans...

Harvard scientists said they have settled a debate over whether a compound found in red wine activates a gene that keeps cells healthy.

Researchers repeated a 10-year old study using a new method to validate earlier findings that resveratrol turns on a gene that recharges mitochondria, tiny structures that produce fuel for cells. By revving up mitochondria, the agent may protect against aging-related diseases, said David Sinclair, a Harvard Medical School genetics professor and the study’s senior author.

Sinclair’s earlier research was disputed in studies in 2009 and 2010 saying that resveratrol only activated the gene, a sirtuin called SIRT1, in experiments that used a synthetic fluorescent chemical to track activity. Since these chemicals aren’t found in cells or nature, other studies said the effect would only work in lab tests and not in humans. The new study, published today in the journal Science, got rid of the chemical.

“Controversy is a difficult thing to deal with, and I hope this paper gives some clarity to the field,” Sinclair said in a telephone interview.

The Harvard group set out to see if the effect was an artifact of the synthetic chemicals or was something that occurred naturally as well. They swapped out the fluorescent chemicals for a group of naturally occurring amino acids, including tryptophan, and found resveratrol did activate SIRT1.

Resveratrol Drugs
Sinclair’s earlier work led to the formation of Sirtris Pharmaceuticals which focuses on developing drugs from resveratrol. GlaxoSmithKline Plc (GSK) acquired the company in 2008 for $720 million. A little more than two years later, Glaxo shelved development of the lead compound from that acquisition, SRT501, when the medicine didn’t appear to work well enough in cancer patients and worsened kidney damage.

Resveratrol is currently being tested in at least two dozen clinical trials to gauge its effects on human health. It’s also packaged as a natural supplement, with $34 million in U.S. sales last year, according to the Nutrition Business Journal.

Further doubt was cast on resveratrol’s abilities after a prominent researcher and promoter of the compound, Dipak Das, who was the director of the University of Connecticut Health Center’s cardiovascular research center, was found to have fabricated and falsified data in numerous studies...

To contact the reporter on this story: Ryan Flinn in San Francisco at [email protected]

19 Comments to Red Wine Compound Activates Gene Needed for Healthy Cells:

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responsible service of alcohol on Saturday, March 23, 2013 12:27 AM
Red Wine Compound Activates Gene Needed for Healthy Cells.Thank you for imparting more of your own thoughts. Good job!
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melasma on Friday, May 31, 2013 10:52 PM
Red wine components are really important for the health care and this is very nice blog for me thanks..
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Massage Therapy Courses on Wednesday, June 26, 2013 10:21 PM
Red wine is a type of wine made from dark-colored (black) grape varieties.I have been wondering about this issue, so thanks for posting. Pretty cool post. It’s really very nice and useful post.!!

Laser Hair Removal in Sydney on Tuesday, June 04, 2013 3:06 AM
That is so nice that red-wine compound is so good for the healthy cell.Harvard's scientists did very nice and impressive job.
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lasik on Friday, June 21, 2013 12:32 AM
Red wine is a type of wine made from dark-coloured (black) grape varieties. The actual colour of the wine can range from intense violet, typical of young wines.A nice overview given by you here.
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anti aging skin care on Wednesday, June 26, 2013 2:09 AM
The benefits of red wine may include reducing the risk of heart attack.red wine may also protect against hearing loss, too.This article really did turn the light on for me as far as this subject goes.
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That's very interesting that red wine activates a gene that keeps cells healthy and feet.Thank you so much for sharing such a nice and useful information.
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